A four-alarm fire tore through a waterfront warehouse in Red Hook Wednesday afternoon, sending thick black smoke across Brooklyn’s industrial shoreline and drawing more than 100 firefighters to battle the blaze.

The Fire Department received multiple 911 calls at 12:38 p.m. reporting flames erupting from the warehouse at 700 Columbia Street, a sprawling industrial building on Pier 41 that sits between the Red Hook Container Terminal and the Ikea shopping complex.

FDNY officials upgraded the response to four alarms within an hour as flames spread through the structure, which houses multiple businesses including auto repair shops and storage operations. Thick smoke was visible from as far away as Lower Manhattan and Staten Island.

“This was a fast-moving fire in a building with multiple occupancies,” FDNY Deputy Chief Michael Rodriguez told reporters at the scene. “Our companies did an outstanding job containing this before it could spread to adjacent structures.”

No injuries were reported, though two firefighters were treated at the scene for smoke inhalation and released. The cause of the fire remains under investigation by the FDNY Fire Marshal’s office.

The blaze shut down Columbia Street between Halleck and Sigourney streets for more than four hours, backing up truck traffic heading to and from the nearby container terminal. The smoke also triggered air quality alerts for residents in Red Hook and neighboring Carroll Gardens.

“I could smell it from my apartment on Court Street,” said Maria Santos, a Carroll Gardens resident who works from home. “The whole sky was black looking toward the water.”

The warehouse fire comes as news of infrastructure concerns continues to mount across the city’s aging industrial waterfront. The Columbia Street corridor houses dozens of auto body shops, warehouses, and maritime businesses in buildings that date back decades.

Community Board 6, which covers Red Hook, has repeatedly raised concerns about fire safety in the neighborhood’s industrial zone, particularly given the area’s limited access routes and the heavy truck traffic that can complicate emergency response.

“Red Hook is essentially an island when it comes to getting in and out,” said James Brennan, a longtime Red Hook resident and former state assemblyman. “When you have a major emergency like this, every minute counts.”

The fire department’s Marine Division deployed fireboats to attack the blaze from the water side, while ladder companies worked to ventilate the building from Columbia Street. The response included units from Brooklyn, Manhattan, and Queens.

Firefighters had the main body of fire under control by 3:15 p.m., though companies remained on scene through the evening monitoring for hot spots. The building’s roof partially collapsed, and the structure sustained heavy damage throughout.

The incident marked the second major industrial fire in Brooklyn this month. Earlier in January, a three-alarm blaze damaged a warehouse in Sunset Park, highlighting ongoing concerns about fire safety in the borough’s manufacturing districts.

Red Hook has faced particular challenges with emergency response since Hurricane Sandy in 2012, when much of the low-lying neighborhood was flooded. The area’s industrial waterfront, built largely in the early 20th century, sits below sea level and relies on aging infrastructure.

The neighborhood is home to the Red Hook Houses, one of the city’s largest public housing developments, as well as a growing number of small businesses and artists who have moved to the area in recent years as rents have climbed elsewhere in Brooklyn.

Wednesday’s fire also disrupted operations at the Red Hook Container Terminal, one of the city’s busiest cargo facilities. Port Authority officials said container operations were suspended temporarily as a precaution but resumed by evening.

The FDNY’s investigation will focus on the fire’s origin and whether the building met current safety codes. City records show the warehouse has been cited for various violations over the years, though none were considered serious fire hazards.

“We’ll be looking at everything — electrical systems, storage practices, egress routes,” Deputy Chief Rodriguez said. “This type of mixed-use industrial building requires a thorough investigation.”

The fire department has stepped up inspections of industrial buildings citywide following several major blazes in recent years, including deadly fires in Queens and the Bronx that highlighted safety concerns in older commercial structures.

For Red Hook residents, Wednesday’s blaze served as another reminder of their neighborhood’s vulnerability. The area has only one main road connection to the rest of Brooklyn, making evacuation difficult during emergencies.

City Councilmember Alexa Avilés, who represents Red Hook, said she would push for increased fire safety inspections in the area’s industrial zone.

“Our waterfront communities face unique challenges,” Avilés said. “We need to make sure our emergency response capabilities match the risks these neighborhoods face.”

The warehouse owner could not immediately be reached for comment. The building’s tenants, including several auto repair businesses, are working with the Red Cross to find temporary locations while the damage is assessed.